Cyclin D1 anticorps (AA 147-175)

N° du produit ABIN389145

Cet anticorps anti-Cyclin D1 est un anticorps Lapin Polyclonal détectant Cyclin D1 dans WB. Adapté pour Humain. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour Cyclin D1 anticorps (AA 147-175) (ABIN389145)

Antigène: Cyclin D1 (CCND1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cyclin D1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB14995

Détail du produit anti-Cyclin D1 anticorps

Épitope: AA 147-175

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This CCND1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-175 amino acids from the Central region of human CCND1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-Cyclin D1 (ABIN389145)

Ling, Song, Fan, Feng, Liu, Yang, Wang, Li, Tian, Zhao, Liu, Huang, Hou, Xu, Shi, Li: "Combination of metformin and sorafenib suppresses proliferation and induces autophagy of hepatocellular carcinoma via targeting the mTOR pathway." dans: International journal of oncology, Vol. 50, Issue 1, pp. 297-309, (2017) (PubMed).

Ling, Feng, Ke, Fan, Li, Li, Dong, Wang, Xu, Li, Wang: "Metformin inhibits proliferation and enhances chemosensitivity of intrahepatic cholangiocarcinoma cell lines." dans: Oncology reports, Vol. 31, Issue 6, pp. 2611-8, (2014) (PubMed).

Détails sur Cyclin D1

Antigène: Cyclin D1 (CCND1)

Autre désignation: CCND1

Sujet: CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of the gene encoding this protein, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Poids moléculaire: 33729

ID gène: 595

UniProt: Q6FI00

Pathways: Signalisation PI3K-Akt, Cycle Cellulaire, Mitotic G1-G1/S Phases, ER-Nucleus Signaling